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The individual studies, published in Cephalgia in 2010, and the pooled results, published in Headache in 2010, both showed a significant decrease in the number of headache days (per 28 days) with eight to nine fewer headache days at 24 weeks as well as a significant improvement in quality of life in the Botox group

Shelf Life: Once reconstituted, the solution should be refrigerated at 2C to 8C and utilized within 14 to 21 days to ensure maximum potency

So it stands to reason that if you take rituximab, your body wont mount as full a response in creating antibodies after receiving a vaccine